Authors Sikandar, S; Zahoor, AF; Ahmad, S; Anjum, MN; Ahmad, MN; Shah, MSU in BENTHAM SCIENCE PUBL LTD published article about EFFICIENT SYNTHESIS; IONIC LIQUID; MOLLUSCICIDAL ACTIVITY; BIOLOGICAL EVALUATION; FRIENDLY SYNTHESIS; AQUEOUS-MEDIUM; L-PROLINE; PYRANOPYRAZOLES; GREEN; 4-COMPONENT in [Sikandar, Sana; Zahoor, Ameer Fawad; Shah, Muhammad Sami Ullah] Govt Coll Univ, Dept Chem, Faisalabad 38000, Pakistan; [Ahmad, Sajjad] Univ Engn & Technol Lahore, Dept Chem, Faisalabad Campus, Faisalabad 38000, Pakistan; [Anjum, Muhammad Naveed; Ahmad, Mirza Nadeem] Govt Coll Univ, Dept Appl Chem, Faisalabad 38000, Pakistan in 2020.0, Cited 59.0. Product Details of 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4
Background: The pyrano[2,3-c]pyrazole derivatives are important building blocks of many biologically active compounds owing to their diverse biological potential for example, anti-inflammatory, anticancer, anti-microbial and anti-oxidant properties. Objective: Keeping in mind the wide range of applications of pyrano[2,3-c]pyrazoles, herein we intended to develop a novel synthetic methodology for dihydropyranopyrazoles. We were also interested in determining the influence of amino acids and dipeptides as a catalyst on the synthesis of pyrano[2,3-c]pyrazole derivatives. Methods: To achieve our objectives, we used a one-pot multi-component reaction of ethyl 3-oxobutanoate, propanedinitrile, hydrazine monohydrate and several substituted benzaldehydes by using different catalysts and solvents to synthesize our desired products in the presence of various catalysts. Results and discussion: We found that optimal conditions for the preparation of pyrano[2,3-c]pyrazoles were L-cysteine (0.5 mol) in the presence of water:ethanol (9:1) at 90 degrees C. Various 1,4-dihydropyrano[2,3-c]pyrazoles were afforded by using several substituted benzaldehydes in 66-97% yields. Conclusion: We described a green and environmentally benign method to synthesize pyrano[2,3-c]pyrazoles in a one-pot four component reaction of ethyl 3-oxobutanoate, propanedinitrile, hydrazine monohydrate and different substituted benzaldehyde in the presence of L-cysteine in aqueous ethanol (9:1) at 90 degrees C. Excellent yields of the products, simple work-up, easily available starting materials, use of green solvents, naturally occurring catalyst, non-toxicity, non-chromatographic purification and environmentally benign reaction conditions are some main advantages of this protocol.
Product Details of 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Sikandar, S; Zahoor, AF; Ahmad, S; Anjum, MN; Ahmad, MN; Shah, MSU or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles