Chemical Research in 1008-89-5

Although many compounds look similar to this compound(1008-89-5)COA of Formula: C11H9N, numerous studies have shown that this compound(SMILES:C1(C2=CC=CC=C2)=NC=CC=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

COA of Formula: C11H9N. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Unambiguous Intracellular Localization and Quantification of a Potent Iridium Anticancer Compound by Correlative 3D Cryo X-Ray Imaging. Author is Conesa, Jose Javier; Carrasco, Ana C.; Rodriguez-Fanjul, Vanessa; Yang, Yang; Carrascosa, Jose L.; Cloetens, Peter; Pereiro, Eva; Pizarro, Ana M..

The iridium half-sandwich complex [Ir(η5:κ1-C5Me4CH2py)(2-phenylpyridine)]PF6 is highly cytotoxic: 15-250× more potent than clin. used cisplatin in several cancer cell lines. We have developed a correlative 3D cryo x-ray imaging approach to specifically localize and quantify iridium within the whole hydrated cell at nanometer resolution By means of cryo soft x-ray tomog. (cryo-SXT), which provides the cellular ultrastructure at 50 nm resolution, and cryo hard x-ray fluorescence tomog. (cryo-XRF), which provides the elemental sensitivity with a 70 nm step size, we have located the iridium anticancer agent exclusively in the mitochondria. Our methodol. provides unique information on the intracellular fate of the metallodrug, without chem. fixation, labeling, or mech. manipulation of the cells. This cryo-3D correlative imaging method can be applied to a number of biochem. processes for specific elemental localization within the native cellular landscape.

Although many compounds look similar to this compound(1008-89-5)COA of Formula: C11H9N, numerous studies have shown that this compound(SMILES:C1(C2=CC=CC=C2)=NC=CC=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles