Computed Properties of C7H5F3O. In 2020 PEST MANAG SCI published article about ACETOLACTATE SYNTHASE; COMPUTATIONAL DESIGN; RESISTANCE; HERBICIDES; MUTATIONS; EVOLUTION; WEEDS in [Qu, Ren-Yu; Yang, Jing-Fang; Chen, Qiong; Yang, Wen-Chao; Yang, Guang-Fu] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol, Coll Chem,Chem Biol Ctr,Minist Educ, Wuhan, Peoples R China; [Niu, Cong-Wei; Xi, Zhen] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin, Peoples R China; [Yang, Guang-Fu] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin, Peoples R China in 2020, Cited 40. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.
BACKGROUND Intensifying weed resistance has challenged the use of existing acetohydroxyacid synthase (AHAS)-inhibiting herbicides. Hence, there is currently an urgent requirement for the discovery of a new AHAS inhibitor to effectively control AHAS herbicide-resistant weed species produced by target mutation. RESULTS To combat weed resistance caused by AHAS with P197L mutation, we built a structure library consisting of pyrimidinyl-salicylic acid derivatives. Using the pharmacophore-linked fragment virtual screening (PFVS) approach, hit compound 8 bearing 6-phenoxymethyl substituent was identified as a potential AHAS inhibitor with antiresistance effect. Subsequently, derivatives of compound 8 were synthesized and evaluated for their inhibitory activities. The study of the enzyme-based structure-activity relationship and structure-resistance relationship studies led to the discovery of a qualified candidate, 28. This compound not only significantly inhibited the activity of wild-type Arabidopsis thaliana (At) AHAS and P197L mutant, but also exhibited good antiresistance properties (RF = 0.79). Notably, compared with bispyribac at 37.5-150 g of active ingredient per hectare (g a.i. ha(-1)), compound 27 exhibited higher growth inhibition against both sensitive and resistant Descurainia sophia, CONCLUSION The title compounds have great potential to be developed as new leads to effectively control herbicide-resistant weeds comprising AHAS with P197L mutation. Also, our study provided a positive case for discovering novel, potent and antiresistance inhibitors using a fragment-based drug design approach. (c) 2020 Society of Chemical Industry
About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Qu, RY; Yang, JF; Chen, Q; Niu, CW; Xi, Z; Yang, WC; Yang, GF or concate me.. Computed Properties of C7H5F3O
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