Authors Kamei, Y; Seino, Y; Yamaguchi, Y; Yoshino, T; Maeda, S; Kojima, M; Matsunaga, S in NATURE RESEARCH published article about in [Kamei, Yuji; Seino, Yusuke; Yamaguchi, Yuto; Yoshino, Tatsuhiko; Kojima, Masahiro; Matsunaga, Shigeki] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan; [Maeda, Satoshi] Hokkaido Univ, Inst Chem React Design & Discovery WPI ICReDD, Sapporo, Hokkaido 0010021, Japan; [Maeda, Satoshi] Hokkaido Univ, Fac Sci, Sapporo, Hokkaido 0600810, Japan; [Maeda, Satoshi] JST, ERATO Maeda Artificial Intelligence Chem React De, Sapporo, Hokkaido 0600810, Japan; [Matsunaga, Shigeki] Hokkaido Univ, Global Stn Biosurfaces & Drug Discovery, Sapporo, Hokkaido 0600812, Japan in 2021, Cited 70. Name: (E)-2-Methylbut-2-enoic acid. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1
Hydrogen atom transfer (HAT) hydrogenation has recently emerged as an indispensable method for the chemoselective reduction of unactivated alkenes. However, the hitherto reported systems basically require stoichiometric amounts of silanes and peroxides, which prevents wider applications, especially with respect to sustainability and safety concerns. Herein, we report a silane- and peroxide-free HAT hydrogenation using a combined cobalt/photoredox catalysis and ascorbic acid (vitamin C) as a sole stoichiometric reactant. A cobalt salophen complex is identified as the optimal cocatalyst for this environmentally benign HAT hydrogenation in aqueous media, which exhibits high functional-group tolerance. In addition to its applicability in the late-stage hydrogenation of amino-acid derivatives and drug molecules, this method offers unique advantage in direct transformation of unprotected sugar derivatives and allows the HAT hydrogenation of unprotected C-glycoside in higher yield compared to previously reported HAT hydrogenation protocols. The proposed mechanism is supported by experimental and theoretical studies. Hydrogen atom transfer (HAT) hydrogenation of alkenes usually requires stoichiometric silanes and peroxides. Here, the authors report a silane- and peroxide-free HAT hydrogenation method using a combined cobalt/photoredox catalysis and vitamin C as a sole stoichiometric reactant.
About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Kamei, Y; Seino, Y; Yamaguchi, Y; Yoshino, T; Maeda, S; Kojima, M; Matsunaga, S or concate me.. Name: (E)-2-Methylbut-2-enoic acid
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