An article C-2-Symmetric Cinchona Alkaloid Derivatives: Versatile Catalysts for the Enantioselective C-C Bond Forming Conjugate Addition of Nucleophiles to Simple alpha,beta-Unsaturated Acyl Pyrazoles WOS:000603432100011 published article about CHIRAL LEWIS-ACID; MICHAEL ADDITION; ASYMMETRIC REACTION; DIELS-ALDER; CYCLOADDITIONS; NITROMETHANE; PROPIOLOYLPYRAZOLES; BENZYLHYDROXYLAMINE; MALONONITRILE; ACTIVATION in [Curran, Simon P.; Fallon, Brendan J.; Connon, Stephen J.] Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Chem, 152-160 Pearse St, Dublin 2, Ireland in 2020, Cited 57. HPLC of Formula: C5H8O2. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1
A single C-2-symmetric squaramide catalyst system allows the facile addition of either malononitrile or benzyl nitroacetate to simple pyrazole-based Michael acceptors with excellent enantiocontrol and at lower catalyst loadings than previously possible. The latter reactions are not diastereoselective, however facile hydrogenolysis leads to decarboxylation and formation of the formal adduct from the addition of nitromethane (a very recalcitrant nucleophile in this chemistry) with excellent yield and enantiocontrol.
About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Curran, SP; Fallon, BJ; Connon, SJ or concate me.. HPLC of Formula: C5H8O2
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles