Recently I am researching about CHAGAS-DISEASE; BENZNIDAZOLE; POSACONAZOLE; CHALLENGES; COMPLEXES; DESIGN, Saw an article supported by the . Published in ELSEVIER in AMSTERDAM ,Authors: da Silva, AA; Maia, PID; Lopes, CD; de Albuquerque, S; Valle, MS. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde. SDS of cas: 120-14-9
Chagas disease is a neglected disease, being one of the leading causes of death from infectious diseases. In view of the severity of this pathology, this work describes the synthesis of new thiosemicarbazones derived from chalcones and dibenzalacetones as potential drugs for the treatment of this disease. The structures of all compounds were elucidated by infrared (IR) and nuclear magnetic resonance (H-1 and C-13 NMR) spectroscopies. The chalcone derived thiosemicarbazones 10-14 were tested against the intracellular amastigote form of the protozoan Trypanosoma cruzi and had their cytotoxicity assessed using LLC-MK2 cells. The compound 10 (IC50 = 12.25 mu M) presented the best activity when compared with the standard drug benznidazole (IC50 = 5.64 mu M). (C) 2021 Elsevier B.V. All rights reserved.
SDS of cas: 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact da Silva, AA; Maia, PID; Lopes, CD; de Albuquerque, S; Valle, MS or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles