Chen, Huayan’s team published research in ACS Medicinal Chemistry Letters in 7 | CAS: 20538-12-9

ACS Medicinal Chemistry Letters published new progress about 20538-12-9. 20538-12-9 belongs to indole-building-block, auxiliary class Indole,Ester,Ether, name is Ethyl 7-methoxy-1H-indole-2-carboxylate, and the molecular formula is C12H13NO3, Name: Ethyl 7-methoxy-1H-indole-2-carboxylate.

Chen, Huayan published the artcileDiscovery of 3-Substituted 1H-Indole-2-carboxylic Acid Derivatives as a Novel Class of CysLT1 Selective Antagonists, Name: Ethyl 7-methoxy-1H-indole-2-carboxylate, the publication is ACS Medicinal Chemistry Letters (2016), 7(3), 335-339, database is CAplus and MEDLINE.

The indole I was identified as a novel and highly potent and selective CysLT1 antagonist with IC50 values of 0.0059±0.0011 and 15±4 μM for CysLT1 and CysLT2, resp.

ACS Medicinal Chemistry Letters published new progress about 20538-12-9. 20538-12-9 belongs to indole-building-block, auxiliary class Indole,Ester,Ether, name is Ethyl 7-methoxy-1H-indole-2-carboxylate, and the molecular formula is C12H13NO3, Name: Ethyl 7-methoxy-1H-indole-2-carboxylate.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles