Chen, Hu published the artcileA copper-catalyzed aerobic domino process for the synthesis of isoindolin-1-ylidene derivatives, Synthetic Route of 167015-84-1, the publication is Tetrahedron (2015), 71(22), 3632-3636, database is CAplus.
A convenient and efficient copper-catalyzed aerobic cascade reaction was developed for the synthesis of the pharmacol. relevant isoindolin-1-ylidene scaffold. Various ortho-formyl cinnamates could react smoothly with different amines in the presence of a com. available copper catalyst under mild aerobic conditions. Isoindolin-1-ylidene derivatives were assembled in one pot in moderate to good yields. This method features amine annulation and double dehydrogenation, representing high at. efficiency. Its product could be further converted to the privileged isoindolinone pharmacophore.
Tetrahedron published new progress about 167015-84-1. 167015-84-1 belongs to indole-building-block, auxiliary class Indols, name is tert-Butyl 3-(2-aminoethyl)-1H-indole-1-carboxylate, and the molecular formula is C15H20N2O2, Synthetic Route of 167015-84-1.
Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles