Chen, Ye-Hui published the artcileOrganocatalytic Enantioselective Synthesis of Atropisomeric Aryl-p-Quinones: Platform Molecules for Diversity-Oriented Synthesis of Biaryldiols, Application of 2-(tert-Butyl)-5-chloro-1H-indole, the main research area is aryl quinone enantioselective preparation organocatalyst diversity oriented biaryldiol; atropisomerism; biaryls; chirality; organocatalysis; quinones.
Presented here is a class of novel axially chiral aryl-p-quinones as platform mols. for the preparation of non-C2 sym. biaryldiols. Two sets of aryl-p-quinone frameworks were synthesized with remarkable enantiocontrol by chiral phosphoric acid catalyzed enantioselective arylation of p-quinones by central-to-axial chirality conversion. These aryl-p-quinones were then used to access a wide spectrum of highly functionalized non-C2 sym. biaryldiols with excellent retention of the enantiopurity.
Angewandte Chemie, International Edition published new progress about Arylation catalysts, stereoselective (oxidative). 69622-40-8 belongs to class indole-building-block, name is 2-(tert-Butyl)-5-chloro-1H-indole, and the molecular formula is C12H14ClN, Application of 2-(tert-Butyl)-5-chloro-1H-indole.
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles