Vinyl nosylates as partner in copper and silver co-catalyzed Sonogashira cross-coupling reactions was written by Cheval, Nicolas P.;Hoffmann, Barbara;Dikova, Anna;Sirindil, Fatih;Bertus, Philippe;Blanc, Aurelien;Weibel, Jean-Marc;Pale, Patrick. And the article was included in Tetrahedron in 2018.Reference of 14396-90-8 This article mentions the following:
Vinyl nosylates, readily obtained from 尾-dicarbonyl derivatives, could be efficiently engaged in Sonogashira cross-coupling reactions, co-catalyzed by either copper or silver salts. The para-nitrobenzenesulfonate (nosylate) group allows this coupling to be performed under very mild conditions (room temperature). This new leaving group and mild conditions could be applied to the synthesis of acetylenic coumarinyl derivatives and to the total synthesis of an acetylenic monoterpene natural product, cleviolide. In the experiment, the researchers used many compounds, for example, 2-(But-3-yn-1-yl)isoindoline-1,3-dione (cas: 14396-90-8Reference of 14396-90-8).
2-(But-3-yn-1-yl)isoindoline-1,3-dione (cas: 14396-90-8) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Reference of 14396-90-8
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles