Synthesis of New Fluorogenic Cyanine Dyes and Incorporation into RNA Fluoromodules was written by Constantin, Tudor P.;Silva, Gloria L.;Robertson, Kelly L.;Hamilton, Tamara P.;Fague, Kaitlin;Waggoner, Alan S.;Armitage, Bruce A.. And the article was included in Organic Letters in 2008.HPLC of Formula: 171429-43-9 This article mentions the following:
A new fluorogenic cyanine dye was synthesized and found to have low fluorescence quantum yield in fluid solution and in the presence of double-stranded DNA but 80-fold enhanced fluorescence in viscous glycerol solution An RNA aptamer selected for binding to the new dye exhibits Kd = 87 nM and 60-fold fluorescence enhancement. The dye-aptamer pair is a fluoromodule that can be incorporated into fluorescent sensors and labels. In the experiment, the researchers used many compounds, for example, 1-(5-Carboxypentyl)-2,3,3-trimethyl-3H-indol-1-ium bromide (cas: 171429-43-9HPLC of Formula: 171429-43-9).
1-(5-Carboxypentyl)-2,3,3-trimethyl-3H-indol-1-ium bromide (cas: 171429-43-9) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.HPLC of Formula: 171429-43-9
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles