So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tailor, Sanita B.; Manzotti, Mattia; Smith, Gavin J.; Davis, Sean A.; Bedford, Robin B. researched the compound: 2-Phenylpyridine( cas:1008-89-5 ).Safety of 2-Phenylpyridine.They published the article 《Cobalt-Catalyzed Coupling of Aryl Chlorides with Aryl Boron Esters Activated by Alkoxides》 about this compound( cas:1008-89-5 ) in ACS Catalysis. Keywords: biaryl preparation transmetalation key step kinetics linear free energy; aryl chloride boron reagent alkoxide Suzuki coupling cobalt catalyst. We’ll tell you more about this compound (cas:1008-89-5).
The cobalt-catalyzed Suzuki biaryl cross-coupling of aryl chloride substrates with aryl boron reagents, activated with more commonly used bases, remained a significant unmet challenge in the race to replace platinum group metal catalysts with Earth-abundant metal alternatives. This highly desirable process can be realized using alkoxide bases, provided the right counterion is employed, strict stoichiometric control of the base is maintained with respect to the aryl boron reagent, and the correct boron ester is selected. Potassium tert-butoxide works well, but any excess of the base first inhibits and then poisons the catalyst. Lithium tert-butoxide performs very poorly, while even catalytic amounts of lithium additives also poison the catalyst. Meanwhile, a neopentane diol-based boron ester is required for best performance. As well as delivering this sought-after transformation, a detailed mechanistic and computational investigations to probe the possible mechanism of the reaction has been discussed and explains the unexpected exptl. observations.
If you want to learn more about this compound(2-Phenylpyridine)Safety of 2-Phenylpyridine, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1008-89-5).
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles