Improved synthesis of 3-spiro indolines in dry media under microwave irradiation was written by Dandia, Anshu;Sachdeva, Harshita;Singh, Ruby. And the article was included in Synthetic Communications in 2001.Synthetic Route of C8H4N2O4 This article mentions the following:
The spiro[indole-dipyrrolopyridines] I (X = NH; R = H, Me; R1, R2 = F, H; H, NO2; Me, Me; NO2, H; H, NO2) were prepared in an efficient, one-pot synthesis using microwave irradiation by reaction of spiro[indole-dipyrrolopyrans] I (X = O) with ammonium acetate in the presence of acetic acid. I (X = O) were prepared in situ by microwave induced reaction of indole-2,3-diones and 2-pyrrolidones in a 1:2 molar ratio. Comparative studies were made between microwave irradiation of reactants in the absence of any solvent and catalyzed reactions in the presence of o-dichlorobenzene and classical heating. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Synthetic Route of C8H4N2O4).
7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Synthetic Route of C8H4N2O4
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles