New N-pyridinyl(methyl)indolalkanamides acting as topical inflammation inhibitors was written by Dassonville, Alexandra;Breteche, Anne;Evano, Johan;Duflos, Muriel;le Baut, Guillaume;Grimaud, Nicole;Petit, Jean-Yves. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Application In Synthesis of 3-(1H-Indol-1-yl)propanoic acid This article mentions the following:
Title compounds were prepared as non-acidic NSAIDs. Pharmacomodulation was carried out at N(1) and C(5) of the indole ring and at the level of the propanamide chain. N-(Pyridin-3-ylmethyl)-3-[5-chloro-1-(4-chlorobenzyl)indol-3-yl]propanamide represents one of the most potent compounds evaluated in the TPA-induced mouse ear swelling assay, with a level of activity higher than that of ibuprofen and comparable to that of dexamethasone. In the experiment, the researchers used many compounds, for example, 3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1Application In Synthesis of 3-(1H-Indol-1-yl)propanoic acid).
3-(1H-Indol-1-yl)propanoic acid (cas: 6639-06-1) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Application In Synthesis of 3-(1H-Indol-1-yl)propanoic acid
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles