Davies, Huw M. L.’s team published research in Journal of the American Chemical Society in 128 | CAS: 27784-79-8

Journal of the American Chemical Society published new progress about 27784-79-8. 27784-79-8 belongs to indole-building-block, auxiliary class Other Aromatic Heterocyclic,Bromide,Ketone, name is 2-Bromo-6,7-dihydro-1H-indol-4(5H)-one, and the molecular formula is C8H8BrNO, Category: indole-building-block.

Davies, Huw M. L. published the artcileC-H Activation as a Strategic Reaction: Enantioselective Synthesis of 4-Substituted Indoles, Category: indole-building-block, the publication is Journal of the American Chemical Society (2006), 128(4), 1060-1061, database is CAplus and MEDLINE.

A method is described for the asym. synthesis of 4-substituted indoles, e.g., I, from the Rh2(S-DOSP)4-catalyzed decomposition of vinyldiazoacetates in the presence of N-Boc-4-acetoxy-6,7-dihydroindole. The reaction proceeds via a combined C-H activation/Cope rearrangement-elimination mechanism resulting in good yields and very high asym. induction. The absolute configuration of I was determined by X-ray crystallog. of its reduced analog.

Journal of the American Chemical Society published new progress about 27784-79-8. 27784-79-8 belongs to indole-building-block, auxiliary class Other Aromatic Heterocyclic,Bromide,Ketone, name is 2-Bromo-6,7-dihydro-1H-indol-4(5H)-one, and the molecular formula is C8H8BrNO, Category: indole-building-block.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles