Efficient synthesis and resolution of pyrrolizidines was written by de Figueiredo, Renata Marcia;Froehlich, Roland;Christmann, Mathias. And the article was included in Angewandte Chemie, International Edition in 2007.Name: 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid This article mentions the following:
In only two steps the com. available maleimide I is converted into the key pyrrolizidine carboxylic acid unit II of the telomerase inhibitor UCS1025A. A kinetic resolution through an enantioselective oxa-Michael lactonization and trituration of the resulting scalemic mixture allow for a virtually quant. separation of a racemate into the enantiomers. In the experiment, the researchers used many compounds, for example, 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4Name: 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid).
4-(1,3-Dioxoisoindolin-2-yl)butanoic acid (cas: 3130-75-4) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Name: 4-(1,3-Dioxoisoindolin-2-yl)butanoic acid
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles