On June 4, 2009, Deng, Jianghe; Kerns, Jeffrey K.; Jin, Qi; Lin, Guoliang; Lin, Xichen; Lindenmuth, Michael; Neipp, Christopher; Nie, Hong; Thomas, Sonia M.; Widdowson, Katherine L. published a patent.Safety of Methyl 5-bromoindoline-7-carboxylate The title of the patent was Preparation of novel indolecarboxamides as IKK2 inhibitors. And the patent contained the following:
The title compounds I [R1 = XYZ, tetrahydroisoquinolinyl, dihydroisoindolyl; X = (un)substituted Ph, heteroaryl, etc.; Y = a bond or alkylene; Z = NR4R5 or heterocycloalkyl; R2, R3 = H, F, Cl; R4 = H, alkyl (optionally substituted with one hydroxy or one methoxy group); R5 = H, heterocycloalkyl, alkoxy, etc.; U = a bond, alkylene or alkenylene; V = Ph, 5-6 membered heteroaryl, 5-7 membered heterocycloalkyl, etc.] which are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease), were prepared E.g., a multi-step synthesis of II, starting from indoline, was given. Selected compounds I were tested for activity against IKK2 (data given for representative compounds I). The invention is further directed to pharmaceutical compositions comprising a compound I. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound I or a pharmaceutical composition comprising a compound I. The experimental process involved the reaction of Methyl 5-bromoindoline-7-carboxylate(cas: 860624-88-0).Safety of Methyl 5-bromoindoline-7-carboxylate
The Article related to indolecarboxamide preparation ikk2 inhibitor antirheumatic antiasthmatic copd treatment, indole amide preparation ikk2 inhibitor antirheumatic antiasthmatic copd treatment and other aspects.Safety of Methyl 5-bromoindoline-7-carboxylate
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles