Synthesis and screening of 3-(4-oxo-2-phenyl-1,3-thiazol-5(4H)-ylidene)-1,3-dihydro-2H-indol-2-one-N-methylanilines for antiinflammatory activity was written by Devi, N. Saritha;Srinivas, B.;Sarangapani, Manda. And the article was included in Journal of Pharmaceutical Sciences and Research in 2019.Name: 7-Nitroindoline-2,3-dione This article mentions the following:
A novel 3-(4-oxo-2-phenyl-1,3-thiazol-5(4H)-ylidene)-1,3-dihydro-2H-indol-2-one -N-methylaniline derivatives I [R = 5-Cl, 7-Me, 5,6-di-Cl, etc.] was synthesized by cyclization of isatins with thiazolidinone. The compounds I [R = 5-F, 5-Cl, 7-Cl, 5-Br, 5,6-di-Cl, 5-OH] were evaluated for in vivo antiinflammatory activity. The compound I [R = 5,6-di-Cl] showed more in vivo antiinflammatory activity with 72.5% of inhibition among test compounds The compound I [R = 5-F, 5-Cl, 7-Cl, 5-Br, 5-OH] were next in the order of exhibiting in vivo antiinflammatory activity with 65.75, 63.0, 52.5, 61.25 and 51.25 % resp., when compared to standard drug Indomethacin with 73.7% of inhibition. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Name: 7-Nitroindoline-2,3-dione).
7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Name: 7-Nitroindoline-2,3-dione
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles