《Identification of β carbolines isolated from fluorescent human lens proteins》 was published in Nature (London, United Kingdom) in 1976. These research results belong to Dillon, James; Spector, Abraham; Nakanishi, Koji. Application of 59132-30-8 The article mentions the following:
The fluorescent 43,000 mol. weight protein (C1) obtained on alk. degradation of the insoluble or high mol. weight protein fraction of human lens gave 2 fully aromatic β-carbolines (I and II) on decomposition or oxidation These β-carbolines were also obtained on decomposition or oxidation of 3,4-dihydro-β-carboline 3-carboxylic acids (III and IV) showing that C1 is a mit. of III and IV. Protein hydrolysates from 45- and 77-year-old but not young human lens contained I and II, suggesting that there is an age-dependent formation of the β-carboline skeleton in human lens. Preliminary experiments suggested 1,2,3,4-tetrahydro-β-carboline 1,3-dicarboxylic acid (V) and its 1-Me derivative (VI) are the in vivo precursors of IV and III, resp. The experimental part of the paper was very detailed, including the reaction process of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8Application of 59132-30-8)
2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Application of 59132-30-8They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles