(NH4)2S2O8-Mediated Metal-Free Decarboxylative Formylation/Acylation of α-Oxo/Ketoacids and Its Application to the Synthesis of Indole Alkaloids was written by Dinesh, Votarikari;Nagarajan, Rajagopal. And the article was included in Journal of Organic Chemistry in 2022.COA of Formula: C9H6ClNO This article mentions the following:
A metal-free method for the formylation/acylation of indoles and β-carbolines with (NH4)2S2O8 via direct decarboxylative cross-coupling of α-oxo/ketoacids in moderate to good yields is described. The reaction occurs between ambient temperature and 40°C under mild reaction conditions with com. available starting materials. This methodol. can be expanded to some biol. active indole alkaloids like pityriacitrins, eudistomins Y1 and Y3, and marinacarbolines A-D. Safety: all reactions carried out in well-ventilated fume hood. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0COA of Formula: C9H6ClNO).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.COA of Formula: C9H6ClNO
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles