Synthesis and antiproliferatory activities evaluation of multi-substituted isatin derivatives was written by Ding, Ying;Zhao, Lianbo;Fu, Ying;Hao, Lei;Fu, Yupeng;Yuan, Yuan;Yu, Peng;Teng, Yuou. And the article was included in Molecules in 2021.HPLC of Formula: 112656-95-8 This article mentions the following:
A series of multi-substituted isatin derivatives I (R1 = H, F, Cl, Br, OMe; R2 = F, Cl, Me, etc.) were synthesized using the powerful Sandmeyer reaction. Inhibition of proliferation activities of these derivatives against human leukemia cells (K562), human hepatocellular carcinoma cells (HepG2) and human colon carcinoma cells (HT-29) were evaluated in vitro using the MTT assay. Among the series, compound I (R1 = F; R2 = Br) exhibited strong antiproliferatory activities against K562, HepG2 and HT-29 cells with IC50 values of 1.75, 3.20, and 4.17μM, resp. The morphol., growth inhibitory and apoptosic effects of compound I (R1 = F; R2 = Br) in K562 cells, wound healing effect in HepG2 cells, and tube formatting effect in matrix gel of HUVEC cells were evaluated consequently. All results indicated that compound I (R1 = F; R2 = Br) could be used as a potential antitumor agent in further investigations. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8HPLC of Formula: 112656-95-8).
7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.HPLC of Formula: 112656-95-8
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles