Cobalt-Catalyzed Intramolecular Olefin Hydroarylation Leading to Dihydropyrroloindoles and Tetrahydropyridoindoles was written by Ding, Zhenhua;Yoshikai, Naohiko. And the article was included in Angewandte Chemie, International Edition in 2013.Name: 5-Chloroindole-3-carboxaldehyde This article mentions the following:
The authors developed an intramol. olefin hydroarylation reaction using a cobalt nitrogen-heterocyclic carbene (NHC) as a catalyst. The title compounds thus formed included dihydropyrroloindole derivatives and tetrahydropyridoindole derivatives The synthesis of the target compounds was achieved by a directed carbon-hydrogen bond (C-H bond) activation. Cobalt bromide (CoBr2), 4,5-dihydro-1,3-bis(2,4,6-trimethylphenyl)-1H-imidazolium chloride (SImes chloride) was used as catalyst combination and [(Trimethylsilyl)methyl]magnesium chloride (Grignard reagent) was used as additive. A cyclization of N-[[1-(3-butenyl)-1H-indol-3-yl]methylene]-4-methoxybenzenamine (I) (indole alkene imine Schiff base) gave a pyrrolo[1,2-a]indolecarboxaldehyde derivative (II) and 6,7,8,9-tetrahydropyrido[1,2-a]indole-10-carboxaldehyde (III). In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Name: 5-Chloroindole-3-carboxaldehyde).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Name: 5-Chloroindole-3-carboxaldehyde
Referemce:
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles