HPLC of Formula: C7H8O. In 2019.0 MOLECULES published article about CARCINOMA-CELLS; ACID; EXPRESSION; PROTEINS; GROWTH; DEATH; LUNG; VIVO; METASTASIS; INHIBITOR in [Mahajna, Shahinaz; Kadan, Sleman; Saad, Bashar; Zaid, Hilal] Al Qasemi Acad Coll, Qasemi Res Ctr, POB 124, IL-30100 Baqa El Gharbia, Israel; [Mahajna, Shahinaz; Ginsberg, Doron] Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-5299 Ramat Gan, Israel; [Kadan, Sleman] Hebrew Univ Jerusalem, Inst Chem, Casali Ctr Appl Chem, IL-91904 Jerusalem, Israel; [Tietel, Zipora] Volcani Ctr, ARO, Dept Postharvest Sci Fresh Produce, IL-7505101 Bet Dagan, Israel; [Saad, Bashar; Khasib, Said; Tumeh, Aziz; Zaid, Hilal] Arab Amer Univ, Fac Sci, POB 240, Jenin 009704, Palestine in 2019.0, Cited 79.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.
Naturally derived drugs and plant-based products are attractive commodities that are being explored for cancer treatment. This in vitro study aimed to investigate the role of Hypericum triquetrifolium (50% ethanol: 50% water) extract (HTE) treatment on apoptosis, cell cycle modulation, and cell cycle arrest in human colon cancer cell line (HCT-116). HTE induced cell death via an apoptotic process, as assayed by an Annexin V-Cy3 assay. Exposing HCT-116 cells to 0.064, 0.125, 0.25, and 0.5 mg/mL of HTE for 24 h led to 50 +/- 9%, 71.6 +/- 8%, 85 +/- 5%, and 96 +/- 1.5% apoptotic cells, respectively. HCT-116 cells treated with 0.25 and 0.5 mg/mL HTE for 3 h resulted in 38.9 +/- 1.5% and 57.2 +/- 3% cleavage of caspase-3-specific substrate, respectively. RT-PCR analysis revealed that the HTE extract had no effect on mRNA levels of Apaf-1 and NOXA. Moreover, the addition of 0.125 mg/mL and 0.25 mg/mL HTE for 24 h was clearly shown to attenuate the cell cycle progression machinery in HCT-116 cells. GC/MS analysis of the extract identified 21 phytochemicals that are known as apoptosis inducers and cell cycle arrest agents. All the compounds detected are novel in H. triquetrifolium. These results suggest that HTE-induced apoptosis of human colon cells is mediated primarily through the caspase-dependent pathway. Thus, HTE appears to be a potent therapeutic agent for colon cancer treatment.
HPLC of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Mahajna, S; Kadan, S; Tietel, Z; Saad, B; Khasib, S; Tumeh, A; Ginsberg, D; Zaid, H or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles