Huang, CY; Li, JP; Wang, JQ; Zheng, QS; Li, ZH; Tu, T in [Huang, Changyu; Li, Jinpeng; Wang, Jiaquan; Zheng, Qingshu; Li, Zhenhua; Tu, Tao] Fudan Univ, Shanghai Key Lab Mol Catalysis & Innovat Mat, Dept Chem, Shanghai 200438, Peoples R China; [Tu, Tao] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China; [Tu, Tao] Zhengzhou Univ, Green Catalysis Ctr & Coll Chem, Zhengzhou 450001, Peoples R China published Hydrogen-bond-assisted transition-metal-free catalytic transformation of amides to esters in 2021, Cited 45. HPLC of Formula: C7H8O2. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5.
The amide C-N cleavage has drawn a broad interest in synthetic chemistry, biological process and pharmaceutical industry. Transition-metal, luxury ligand or excess base were always vital to the transformation. Here, we developed a transition-metal-free hydrogen-bond-assisted esterification of amides with only catalytic amount of base. The proposed crucial role of hydrogen bonding for assisting esterification was supported by control experiments, density functional theory (DFT) calculations and kinetic studies. Besides broad substrate scopes and excellent functional groups tolerance, this base-catalyzed protocol complements the conventional transition-metal-catalyzed esterification of amides and provides a new pathway to catalytic cleavage of amide C-N bonds for organic synthesis and pharmaceutical industry.
HPLC of Formula: C7H8O2. Welcome to talk about 150-76-5, If you have any questions, you can contact Huang, CY; Li, JP; Wang, JQ; Zheng, QS; Li, ZH; Tu, T or send Email.
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,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles