1,3-Iodo-amination of 2-methyl indoles via C-sp2-C-sp3 dual functionalization with iodine reagent
A 1,3-iodo-amination with iodine reagent that involved the C-sp2-C-sp3 dual functionalization of 2-methyl indoles was developed to provide 2-aminomethyl-3-iodo-indole derivatives. The iodoamination proceeded via a 1,4-transfer of an imide group through the formation of an indolyl(phenyl) iodonium imide using PhI(OAc)(2), followed by an iodination using DIH or a double iodination of indole using excess DIH.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles