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An experimental and theoretical study on the prototropic equilibria of the four carboline isomers
We have determined the experimental pK(a)s for the pyridine protonation and pyrrole deprotonation equilibria of the four isomeric (alpha-, beta-, gamma-, and delta-) carbolines (pyridoindoles) and for the deprotonation of their N-pyrido methylated derivatives. HF 6-31+G* ab initio calculations have been carried out to obtain theoretically the magnitudes of the prototropic equilibria ion gas phase and in solution. A cavity model of solvation has been employed. To analyze the influence of annelation and tautomerism, prototropic equilibria of azaindole isomers and H-pyrido tautomers of carbolines, respectively, have also been theoretically studied. Equilibria involving tautomeric species are always energetically unfavored against those of the normal forms. Solvation differently affects the relative gas phase values among isomers within the series and between the same isomers of related series. Solvent damps the magnitude of the gap among azaindole or carboline isomers and can even reverse the acidity sequence. The acidity sequence of theoretical free energies for the pyridine nitrogen deprotonation (gamma < beta < delta < alpha) and pyrrole nitrogen deprotonation (delta < beta < alpha < gamma) processes of the carboline normal forms in solution at 298 K are in quite reasonable agreement with those observed experimentally. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 272-49-1, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 272-49-1, in my other articles.
Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles