Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Li, Zheng, once mentioned the application of 36687-82-8, Name is L-Carnitine Tartrate, molecular formula is C18H36N2O12, molecular weight is 472.49, MDL number is MFCD04974128, category is indole-building-block. Now introduce a scientific discovery about this category, Formula: C18H36N2O12.
Chemoselective aza-Michael addition of indoles to 2-aroyl-1,3-diarylenones
A total of 20 examples of 2-[(1H-indol-1-yl)(aryl)methyl]-1,3-diphenylpropane-1,3-diones were efficiently synthesized by the aza-Michael addition at the N1 position of indoles with 2-aroyl-1,3-diarylenones at room temperature in the presence of potassium hydroxide. The salient features of this protocol are no transition-metal catalysts, mild conditions, high chemoselectivity, high atom economy, high yields, and a simple work-up procedure.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles