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Analysis of an antimicrobial extract prepared from culture broth of the marine-derived actinomycete Streptomyces sp. G278 led to the isolation of ten compounds, 1-10. Two compounds, 2,5-Bis(5-tert-butyl-2-benzoxazolyl)thiophene (1), and 3-hydroxyl-2-methylpyridine (2) were isolated from a natural source for the first time. The structures of the isolated compounds were established by their spectral data analysis, including mass spectrometry, 1D-NMR, 2D-NMR, and X-ray crystallographic analysis in case of compound 3. All isolated compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compounds 1 and 3 selectively inhibited Enterococcus faecalis (MIC: 256 mug/mL). Compound 2 was found to have antibacterial and antifungal activity against Escherichia coli (MIC: 64 mug/mL), Salmonella enterica (MIC: 256 mug/mL), Staphylococcus aureus (MIC: 256 mug/mL), Enterococcus faecalis (MIC: 256 mug/mL), and Candida albicans (MIC: 64 mug/mL). Except for compounds 9 and 10, the other known metabolites (4-8) also exhibited antimicrobial activity.
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Reference：
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles