Recently I am researching about MUKAIYAMA ALDOL REACTION; REACTION 40YEARS; DRUG DISCOVERY; HETEROCYCLES; EXPANSIONS; REAGENTS; LACTONES; ACCESS, Saw an article supported by the NSFCNational Natural Science Foundation of China (NSFC) [91956114]; Hong Kong RGCHong Kong Research Grants Council [16302318]; Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology [BM2012110]; Jiangsu specially appointed professors program. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Huang, H; Zhang, TY; Sun, JW. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol. Name: Mequinol
Mild oxetane opening by soft carbon nucleophiles has been developed for efficient C-C bond formation. In the presence of LiNTf2 or TBSNTf2 as catalyst, silyl ketene acetals were found to be effective nucleophiles to generate a wide range of highly oxygenated molecules, which are key substructure in natural products like polyketides. Furthermore, intramolecular oxetane opening by a styrene-based carbon nucleophile via a Prins-type process was also achieved with Sc(OTf)(3) as catalyst, leading to efficient formation of the useful 2,3-dihydrobenzo[b]oxepine skeleton.
Name: Mequinol. About Mequinol, If you have any questions, you can contact Huang, H; Zhang, TY; Sun, JW or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles