Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 122111-03-9, Name is Gemcitabine hydrochloride, SMILES is O=C1N([C@H]2C(F)(F)[C@H](O)[C@@H](CO)O2)C=CC(N)=N1.Cl, belongs to indole-building-block compound. In a document, author is Qiao, Chang, introduce the new discover, Name: Gemcitabine hydrochloride.
A straightforward Lewis acid-promoted protocol for 3,3′-bisindolylmethanes (BIMs) synthesis by reductive alkylation of indoles at the C3 position with carboxylic acids in the presence of hydrosilane was developed for the first time. Instead of aldehydes, more readily available, stable, and easy-to-handle carboxylic acids have been employed as alternative alkylating agents. As an efficient organocatalyst, B(C6F5)(3) enables the reductive alkylation of various substituted indole derivatives with carboxylic acids with up to 98% yield at room temperature and under neat conditions. This metal-free strategy offers an alternative approach for the direct functionalization of indoles to BIMs with carboxylic acids and such protocol allows selective reduction of carboxylic acid to aldehyde in combination with C-C bond formation.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 122111-03-9 is helpful to your research. Name: Gemcitabine hydrochloride.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles