2-Amino-3-(7-methyl-1H-indol-3-yl)propanoic acid (cas: 17332-70-6) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Electric Literature of C12H14N2O2
Structural, Functional, and Spectroscopic Characterization of the Substrate Scope of the Novel Nitrating Cytochrome P450 TxtE was written by Dodani, Sheel C.;Cahn, Jackson K. B.;Heinisch, Tillmann;Brinkmann-Chen, Sabine;McIntosh, John A.;Arnold, Frances H.. And the article was included in ChemBioChem in 2014.Electric Literature of C12H14N2O2 This article mentions the following:
A novel cytochrome P 450 enzyme, TxtE, was recently shown to catalyze the direct aromatic nitration of L-tryptophan. This unique chem. inspired us to ask whether TxtE could serve as a platform for engineering new nitration biocatalysts to replace current harsh synthetic methods. As a first step toward this goal, and to better understand the wild-type enzyme, we obtained high-resolution structures of TxtE in its substrate-free and substrate-bound forms. We also screened a library of substrate analogs for spectroscopic indicators of binding and for production of nitrated products. From these results, we found that the wild-type enzyme accepts moderate decoration of the indole ring, but the amino acid moiety is crucial for binding and correct positioning of the substrate and therefore less amenable to modification. A nitrogen atom is essential for catalysis, and a carbonyl must be present to recruit the 伪B’1 helix of the protein to seal the binding pocket. In the experiment, the researchers used many compounds, for example, 2-Amino-3-(7-methyl-1H-indol-3-yl)propanoic acid (cas: 17332-70-6Electric Literature of C12H14N2O2).
2-Amino-3-(7-methyl-1H-indol-3-yl)propanoic acid (cas: 17332-70-6) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Electric Literature of C12H14N2O2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles