1015460-59-9, 7-Bromo-5H-pyrido[4,3-b]indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
1015460-59-9, To a solution of custom made 7-bromo-5H-pyrido[4,3-?>]indole (0.49 g, 1.98 mmol) in Lambda/,Lambda/’- dimethylformamide (5 mL) was added cesium carbonate (0.32 g, 0.99 mmol) and the mixture was stirred at room temperature for 10 minutes and dimethylcarbonate was added dropwise (334 mu, 3.96 mmol). The reaction mixture was heated at 160C for 3 hours and after cooling, water (20 mL) and ethyl acetate (20 mL) were added to the mixture. The phases were separated and the aqueous phase was extracted with ethyl acetate (2 X 20 mL). The organic phases were combined and dried over Na2S04. The solvent was removed under reduced pressure and the residue was purified on a HP-Sil column using a Biotage Isolera One purification system employing a dichloromethane/methanol gradient (100/0 -> 90/10) to afford the crude title compound (0.36 g, 69 %). 1H NMR (400 MHz, DMSO-cf6) delta = 9.36 (s, 1 H), 8.52 (d, 1 H), 8.21 (d, 1 H), 7.95 (d, 1 H), 7.62 (d, 1 H), 7.45 (dd, 1 H), 3.88 (s, 3H) MS (ESI): m/z = 263.95 [M+H]+
The synthetic route of 1015460-59-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AC IMMUNE SA; PIRAMAL IMAGING SA; KROTH, Heiko; NAMPALLY, Sreenivasachary; MOLETTE, Jerome; GABELLIERI, Emanuele; BENDERITTER, Pascal, Andre, Rene; FROESTL, Wolfgang; SCHIEFERSTEIN, Hanno; MUELLER, Andre; SCHMITT-WILLICH, Heribert; BERNDT, Mathias; WO2015/110263; (2015); A1;,
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