With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1074-86-8,1H-Indole-4-carbaldehyde,as a common compound, the synthetic route is as follows.
Example 1 ethyl 2-(1H-indol-4-yl)-8,9-dimethoxy-3-methyl-5,6-dihydropyrrolo[2,1-a]isoquinoline-1-carboxylate A mixture of 500 mg (1.8 mmol) of ethyl (6,7-dimethoxy-3,4-dihydro-1(2H)-isoquinolinylidene)-ethanoate (Intermediate 2.1), 523 mg (3.61 mmol) of indole-4-carbaldehyde, 281 mg (3.61 mmol) of nitroethane and 61.4 mg (0.72 mmol) of piperidine in 10 ML of ethanol/isopropanol (1:1) was stirred at 80¡ã C. overnight. 40 ML of isopropanol were added, the mixture was cooled to 0¡ã C., and the resulting precipitate was filtered off.The solid was washed with ethanol and dried in vacuo to give the title compound as a white solid.The title compound was readily recrystallized from ethyl acetate to furnish white needles. Yield: (487 mg, 63percent) Melting point [¡ã C.]: 246-247 _
1074-86-8, As the paragraph descriping shows that 1074-86-8 is playing an increasingly important role.
Reference£º
Patent; Niewohner, Ulrich; Niewohner, Maria; Bauser, Marcus; Erguden, Jens-Kerim; Flubacher, Dietmar; Naab, Paul; Repp, Thorsten-Oliver; Stoltefuss, Jurgen; Burkhardt, Nils; Sewing, Andrea; Schauer, Michael; Schlemmer, Karl-Heinz; Weber, Olaf; Boyer, Stephen J.; Miglarese, Mark; Fan, Jianmei; Phillips, Barton; Raudenbush, Brian C.; Wang, Yamin; US2003/236276; (2003); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles