With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1074-86-8,1H-Indole-4-carbaldehyde,as a common compound, the synthetic route is as follows.
General procedure: In a flame-dried Schlenk bottle under argon atmosphere, Grignard reagent B (10.2 mol) was added to the Schlenk bottle. Then, in an ice-water bath, a solution of 1H-indole-4-carbaldehyde A (10 mmol) in anhydrous THF (10 mL) was added to the Schlenk bottle. Subsequently, the reaction mixture was moved to an oil bath, which was refluxed at 70 o C overnight. After the completion of the reaction indicated by TLC, the reaction mixture was quenched by saturated ammonium chloride solution and was extracted by ethyl acetate for three times. The combined organic layer was dried by anhydrous sodium sulfate, which was concentrated under the reduced pressure. The resulted residue was purified through flash chromatography on silica gel to afford the pure 4-indolylmethanols 1.
1074-86-8, As the paragraph descriping shows that 1074-86-8 is playing an increasingly important role.
Reference£º
Article; Liu, Jin-Xi; Zhu, Zi-Qi; Yu, Lei; Du, Bai-Xiang; Mei, Guang-Jian; Shi, Feng; Synthesis; vol. 50; 17; (2018); p. 3436 – 3444;,
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