With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.107516-75-6,Diethyl 1H-indole-2,6-dicarboxylate,as a common compound, the synthetic route is as follows.
Step 5: Synthesis of diethyl l-{(2S)-4-[(tert-butoxycarbonyl)amino]butan-2-yl}-1H- indole-2,6-dicarboxylateTo a suspension of hexane washed 60% sodium hydride in mineral oil (91 mg, 2.3 mmol) in DMF (2.5 mL) under nitrogen atmosphere to 0 C is added a solution of diethyl 1H- indole-2,6-dicarboxylate (619 mg, 2.4 mmol) in DMF (4 mL). The mixture is stirred for 20 min at 0 C and a solution of tert-butyl (6R)-6-methyl-1,2,3-oxathiazinane-3- carboxylate 2,2-dioxide (518 mg, 2.1 mmol) in DMF (2.5 mL) is added. The reaction mixture is stirred for 30 min at 0 C and is warmed to room temperature and stirred for 72 h. Water and NH4C1 solution are added and the mixture is stirred for 15 min. The aqueous mixture is extracted with EtOAc (50 mL) and the organic layer is washed with water, brine, dried (MgS04) and concentrated to afford the title crude compound (1.1 g) which is used in the next step without purification.
107516-75-6, As the paragraph descriping shows that 107516-75-6 is playing an increasingly important role.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOYER, Stephen, James; GAO, Donghong, Amy; GUO, Xin; KIRRANE, Thomas, Martin, Jr.; SARKO, Christopher, Ronald; SNOW, Roger, John; SOLEYMANZADEH, Fariba; ZHANG, Yunlong; WO2011/71716; (2011); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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