Downstream synthetic route of 1092114-59-4

As the paragraph descriping shows that 1092114-59-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1092114-59-4,3-Iodo-1H-indole-5-carbonitrile,as a common compound, the synthetic route is as follows.

1092114-59-4, General procedure: To a 5 mL round bottom flask containing 0.1 g of 3-iodoindole was added 2.0 mL of DMSO followed by NIS (10 mol%) and IBX (3.0 equiv). The resultant reaction mixture was stirred at 30 ¡À 5 C. After completion of the reaction as monitored by TLC analysis, the product was isolated following the work-up procedure described above.

As the paragraph descriping shows that 1092114-59-4 is playing an increasingly important role.

Reference£º
Article; Chandra, Ajeet; Yadav, Navin R.; Moorthy, Jarugu Narasimha; Tetrahedron; vol. 75; 14; (2019); p. 2169 – 2174;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles