1196-70-9, 1H-Indole-6-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: 6-(4-Hydroxy-3-methoxyphenyl)hexa-5-ene-2,4-dione (20 mg, 85 mumol) and B2O3 (11 mg, 0.16 mmol) were dissolved in 0.4 mL of AcOEt. To the stirring mixture at 80C was added a solution of 3-hydroxy-2-methoxybenzaldehyde (16 mg, 0.11 mmol) and tributyl borate (25 muL, 93 mumol) in 0.7 mL of AcOEt. After the reaction mixture was stirred at 80C for 2 hours, n-butylamine (10 muL, 0.10 mmol) was added with additional stirring for 1 hour. The reaction mixture was treated with a solution of 1 N HCl and saturated brine (1:1 mixture), stirred at 50C for 5 min, and neutralized by saturated NaHCO3 aqueous solution. The organic layer was directly chromatographed on silica gel (hexane/AcOEt system or CHCl3/MeOH system) to yield the title compound as a solid (10.2 mg) in 32% yield.
1196-70-9, 1196-70-9 1H-Indole-6-carbaldehyde 2773435, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Article; Okuda, Michiaki; Hijikuro, Ichiro; Fujita, Yuki; Teruya, Takayuki; Kawakami, Hirochika; Takahashi, Takashi; Sugimoto, Hachiro; Bioorganic and Medicinal Chemistry Letters; vol. 26; 20; (2016); p. 5024 – 5028;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles