Category: indole-building-block. In 2021.0 STRUCT CHEM published article about IN-VITRO CYTOTOXICITY; MOLECULAR DOCKING; BIOLOGICAL EVALUATION; DESIGN; PHOTOPHYSICS; DIIMIDE; AGENTS; ASSAY in [Lakshmanan, Sivalingam; Mahalakshmi, K.; Thirumurugan, K.; Ramalakshmi, N.; Antony, S. Arul] Presidency Coll, Dept Chem, Chennai 600005, Tamil Nadu, India; [Lakshmanan, Sivalingam] Bharath Univ, BIHER, Dept Chem, Chennai 600073, Tamil Nadu, India; [Govindaraj, Dharman] Madurai Kamaraj Univ, Sch Chem, Madurai 625021, Tamil Nadu, India in 2021.0, Cited 60.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.
Chalcone derivatives (7a-k) have been synthesized and characterized by H-1-NMR, C-13-NMR, mass, and elemental analysis. The synthesized compounds 7a, 7d, and 7g have been examined and it is confirmed that the most promising cytotoxicity and also cell morphology analysis exhibited good apoptotic activity against lung cancer A549 cell. The free energy binding of compound 7d exhibits – 8.96 kcal/mol with five hydrogen bonding Asn1254, Arg1253, Asp1249, and Gly1123 amino acids of ALK receptors. The LUMO of the electron density present in alpha, beta-double bond and influence the anticancer activity. The Mulliken atomic charges and MEPs are scrutinizing the ligand interaction with the amino acid binding of ALK receptors. UV-visible and photoluminescence spectra showed that the properties of chalcone derivatives have a significant effect on the visible absorption and emission maxima (531-535 nm) red shift in the emission spectra which also systematically investigated electrochemical in various solvents with increasing solvent polarity.
About 4-Methoxybenzaldehyde, If you have any questions, you can contact Lakshmanan, S; Govindaraj, D; Mahalakshmi, K; Thirumurugan, K; Ramalakshmi, N; Antony, SA or concate me.. Category: indole-building-block
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles