Moon, HW; Lee, SJ; Park, SH; Jung, SG; Jung, IA; Seol, CH; Kim, SW; Lee, SM; Gangganna, B; Park, S; Lee, KY; Oh, CY; Song, J; Jung, J; Heo, JS; Lee, KH; Kim, HS; Lee, WT; Baek, A; Shin, H in [Moon, Hyung Wook; Lee, Seung Jong; Park, Seong Hu; Jung, Se Gyo; Jung, In A.; Seol, Chang Hun; Kim, Seung Woo; Lee, Seon Mi; Gangganna, Bogonda; Park, Seokhwi; Lee, Kee-Young; Oh, Chang-Young; Song, Juyoung; Jung, Jaehun; Heo, Ji Soo; Lee, Kang Hee; Kim, Hae Sol; Lee, Won Taek; Baek, Areum; Shin, Hyunik] Yonsung Fine Chem Co Ltd, R&D Ctr, Suwon 16675, Gyeonggi Do, South Korea published Large-Scale Synthesis of Eldecalcitol in 2021.0, Cited 37.0. HPLC of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.
Industrial-scale synthesis of eldecalcitol is described. AA highly diastereoselective epoxidation of p-methoxybenzyl (PMB) protected dienol at room temperature provides the key epoxide intermediate with a secondary hydroxyl group, which is alkylated with a triflate to set up all of the subunits at the C-1, C-2, and C-3 positions of the A-ring fragment. Selective protecting group manipulation followed by palladium-catalyzed cyclization then provides the A-ring synthon. The C/D-ring fragment is obtained by (1) direct C-H hydroxylation of Grundman’s ketone using in situ prepared trifluoropropanone dioxirane and (2) protection. Finally, the coupling of the A-ring with the C/D-ring fragment, global deprotection, and recrystallization provide the highly crystalline eldecalcitol.
HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Moon, HW; Lee, SJ; Park, SH; Jung, SG; Jung, IA; Seol, CH; Kim, SW; Lee, SM; Gangganna, B; Park, S; Lee, KY; Oh, CY; Song, J; Jung, J; Heo, JS; Lee, KH; Kim, HS; Lee, WT; Baek, A; Shin, H or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles