With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.143612-79-7,3-(4-Chlorobutyl)-1H-indole-5-carbonitrile,as a common compound, the synthetic route is as follows.
6-(2-(Piperazin- 1 -yl)pyrimidin-5-yl)nicotinamide dihydrochloride (400 mg, 1.12 mmol), 3-(4-chlorobutyl)-1H-indole-5-nitrile (312 mg, 1.34 mmol), anhydrous sodium carbonate (712 mg, 6.72 mmol) and sodium iodide (50 mg, 0.33 mmol) were added into anhydrous acetonitrile (15 mL) in turn. The solution was heated to 90 C and reacted for 36 hours. The reaction was stopped, and the mixture was cooled to room temperature. The solvent was evaporated under reduced pressure. The residue was purified by column chromatography (dichloromethane/methanol (v/v) = 20/1) to give the title compound as a faint yellow solid (465 mg, 86.4%).MS (ESI, pos. ion) m/z: 481.30 [M+H].?H NIVIR (400 1?IFlz, DMSO-d6) (ppm): 11.36 (s, 1H), 9.08 (s, 2H), 9.04 (d, J= 1.7 Hz,1H), 8.26 (dd, J= 8.3, 2.1 Hz, 1H), 8.14 (s, 1H), 8.10 (s, 1H), 8.05 (d, J= 8.3 Hz, 1H), 7.52 (s,1H), 7.49 (d, J= 8.3 Hz, 1H), 7.40 (dd, J= 8.4, 0.9 Hz, 1H), 7.35 (s, 1H), 3.90 (brs, 4H), 3.39(brs, 4H), 2.73 (t, J 7.4 Hz, 2H), 2.452.39 (m, 2H), 1.731.65 (m, 2H), 1.54 (d, J= 6.7 Hz,2H);HPLC: 95.11%.
143612-79-7, 143612-79-7 3-(4-Chlorobutyl)-1H-indole-5-carbonitrile 9881123, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; JIN, Chuanfei; ZHONG, Wenhe; LIANG, Haiping; ZHANG, Yingjun; (79 pag.)WO2019/62662; (2019); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
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