With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.143612-79-7,3-(4-Chlorobutyl)-1H-indole-5-carbonitrile,as a common compound, the synthetic route is as follows.
The title compound of this step is prepared by the method described in the third step of Example 1,4-methyl-2-(2-(piperazin-1-yl)pyrimidin-5-yl)oxazole-5-carboxamide dihydrochloride (500 mg, 1.38 mmol),3-(4-Chlorobutyl)-1H-indole-5-carbonitrile (386 mg, 1.66 mmol), anhydrous sodium carbonate (878 mg, 8.28 mmol)Sodium iodide (63 mg, 0.42 mmol) was prepared in acetonitrile (15 mL) at 90 C for 36 hours.The obtained crude product was further purified by silica gel chromatography (dichloromethane:methanol (V:V)=30:1) to give the title compound(light yellow solid, 492 mg, 73.6%)., 143612-79-7
143612-79-7 3-(4-Chlorobutyl)-1H-indole-5-carbonitrile 9881123, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Zhong Wenhe; Liang Haiping; Zhang Yingjun; (57 pag.)CN109574993; (2019); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles