Downstream synthetic route of 15317-58-5

15317-58-5, As the paragraph descriping shows that 15317-58-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15317-58-5,1H-Indole-3-carbohydrazide,as a common compound, the synthetic route is as follows.

I H-lndole-3-carbohydrazide (250mg, 1.4mmol) and 1-(4-isothiocyanatobutyl)pyrrolidine (342.5mg, 1.9mmol) was stirred at 600C under argon with THF (10ml) as a solvent. The reaction lasted 1 h. THF was evaporated. The product was triturated with ether. Then it was filtered to obtain 414mg yellow solid.

15317-58-5, As the paragraph descriping shows that 15317-58-5 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2009/71577; (2009); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles