16136-52-0, 4-Cyanoindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 1H-indole-4-carbonitrile (6) (5g, 35.17mmol) in THF (100mL) was added NaH (1.3g, 52.75mmol) at 0C. The mixture was stirred for 5min and benzenesulfonyl chloride (6.5g, 42.21mmol) was then added. The reaction was allowed to room temperature and stirred for an additional 30min and then poured into a precooled saturated aqueous NH4Cl solution (300mL). The aqueous phase was separated and extracted with ethyl acetate (100mL¡Á3); the combined organic layers were washed with water (100mL) and brine (100mL), dried over Na2SO4, filtered and evaporated in vacuo. The residue was recrystallized (EtOAc) to give the 1-(phenylsulfonyl)-1H-indole-4-carbonitrile (7) (7.4g, yield 75%, purity 98%). MS (ESI) m/z 283.1 [M+H]+., 16136-52-0
The synthetic route of 16136-52-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Wang, Xueyuan; Bai, Enhe; Zhou, Hui; Sha, Sijia; Miao, Hang; Qin, Yanru; Liu, Zhaogang; Wang, Jia; Zhang, Haoyang; Lei, Meng; Liu, Jia; Hai, Ou; Zhu, Yongqiang; Bioorganic and Medicinal Chemistry; vol. 27; 3; (2019); p. 533 – 544;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles