With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16732-70-0,Ethyl 5-bromo-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.
Example 88 5-[l-(2-Oxo-pyrrolidin-l-yl)-ethyl]-lH-indole-2-carboxylic acid (3,5-difluoro-phenyl)- amide a) 5-ri-(2-Oxo-pyrrolidin-l-yl)-vinyll-lH-indole-2-carboxylic acid ethyl ester Palladium- (II) -acetat (17 mg) and tri-(o-tolyl)pho spine (68 mg) were dissolved in DMF (10 mL), then 5-bromo-lH-indole-2-carboxylic acid ethyl ester (400 mg), sodium hydrogen carbonate (501 mg), Nu,Nu-diisopropyl ethyl amine (1.02 mL) and l-vinyl-2-pyrrolidon (207 mg) were added. The reaction was stirred at 125C for 1.5 hours, followed by extraction with ethyl acetate and water. Column chromatography on silica gel using heptane / ethyl acetate (1: 1) yielded the title compound as the minor component of the reaction as a light grey solid (161 mg, 36 %). MS ISP (m/e): 299.2 (100) [(M+H)+].
As the paragraph descriping shows that 16732-70-0 is playing an increasingly important role.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BAUMANN, Karlheinz; FLOHR, Alexander; JOLIDON, Synese; KNUST, Henner; LUEBBERS, Thomas; NETTEKOVEN, Matthias; WO2014/60386; (2014); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles