With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16732-70-0,Ethyl 5-bromo-1H-indole-2-carboxylate,as a common compound, the synthetic route is as follows.
A solution of the 3a (0.204 g, 0.5 mmol), ethyl 5-bromo-1Hindole-2-carboxylate (0.134 g, 0.5 mmol), Pd(dppf)2Cl2 (0.018 g,0.025 mmol) and Cs2CO3 (0.33 g, 0.56 mmol) in DMF (10 ml) underan atmosphere of N2 was stirred at 90 C for 4 h. DMF was removedunder reduced pressure and the residue was purified through acolumn chromatography on silica with chloroform/methanol (V:V20:1) as a white solid (0.12 g, 51.2% yield). mp 108-110 C. 1H NMR(400 MHz, DMSO) delta 12.00 (s, 1H, NH), 10.02 (s, 1H, NH), 8.27 (d,J 2.2 Hz, 1H, Ar-H), 7.87-7.80 (m, 4H, Ar-H), 7.55 (d, J 8.6 Hz, 1H,Ar-H), 7.49 (dd, J 8.6, 1.4 Hz, 1H, Ar-H), 7.43 (t, J 8.8 Hz, 2H, Ar-H), 7.22 (d, J 1.5 Hz, 1H, Ar-H), 4.36 (q, J 7.1 Hz, 2H, CH2), 3.66 (s,3H, CH3), 1.36 (t, J 7.1 Hz, 3H, CH3).13C NMR (100 MHz, DMSO)delta 164.8 (J 249.7 Hz), 161.7, 156.4, 141.6, 137.4, 137.1, 137.0, 132.3,131.1, 130.3 (d, J 9.6 Hz), 129.2, 128.7, 127.8, 124.2, 120.6, 120.2,116.7 (d, J 22.8 Hz), 113.8, 108.5, 61.0, 53.8, 14.8. HRMS: m/z470.1181 [MH]., 16732-70-0
As the paragraph descriping shows that 16732-70-0 is playing an increasingly important role.
Reference£º
Article; Fan, Yan-Hua; Li, Wei; Liu, Dan-Dan; Bai, Meng-Xuan; Song, Hong-Rui; Xu, Yong-Nan; Lee, SangKook; Zhou, Zhi-Peng; Wang, Jian; Ding, Huai-Wei; European Journal of Medicinal Chemistry; vol. 139; (2017); p. 95 – 106;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles