With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19012-02-3,3-Acetyl-1-methylindole,as a common compound, the synthetic route is as follows.,19012-02-3
General procedure: To a solution of N-methyl-3-acetylindol (1 mmol) and the benzaldehyde derivative (1 mmol) in methanol (10 ml) was added KOH (1 ml from a 50% solution in H2O). The mixture was heated at 60 C for 12 h then evaporated to dryness. The crude was dissolved in ethyl acetate (30 ml) then washed with HCl (1N, 10 ml) and H2O (10 ml), respectively. The organic layer was separated, dried over Na2SO4 and evaporated. The product was purified by chromatography column eluted with hexane:ethyl acetate (8:2) to yield the title compound as a yellow powder.
19012-02-3 3-Acetyl-1-methylindole 594156, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Article; Martel-Frachet, Veronique; Kadri, Malika; Boumendjel, Ahcne; Ronot, Xavier; Bioorganic and Medicinal Chemistry; vol. 19; 20; (2011); p. 6143 – 6148;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles