With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2380-84-9,1H-Indol-7-ol,as a common compound, the synthetic route is as follows.
[463] To a mixture of 7-hydroxyindole (4.5 g, 33.8 mmol) and THE (200 mL) was added triphenylphosphine (17.7 g, 67.7 mmol), diisopropyl azodicarboxylate (13.3 mL, 67.7 mmol) and 2- chloroethanol (4.5 mL, 67.1 mmol). After stirring at it overnight, the reaction mixture was concentrated in vacuo and the resulting residue was purified by flash column chromatography on silica gel (100% heptane to 10% EtOAc/heptane) to afford 7-(2-chloroethoxy)indole (B1) as a pale yellow oil.
2380-84-9, The synthetic route of 2380-84-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ARIAD PHARMACEUTICALS, INC.; HUANG, Wei-Sheng; LI, Feng; DALGARNO, David, C.; GONG, Yongjin; ISHCHENKO, Alexey, V.; KOHLMANN, Anna; SHAKESPEARE, William, C.; WEST, Angela, V.; XU, Yongjin; YOUNGSAYE, Willmen; ZHANG, Yun; ZHOU, Tianjun; ZHU, Xiaotian; (444 pag.)WO2015/175632; (2015); A1;,
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