With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23872-36-8,4-Chloro-1H-indole-3-carboxylic acid,as a common compound, the synthetic route is as follows.
Step 1 Preparation of 4-chloro-N-((3,3-difluoro-5-methylcyclohexyl)methyl)-1H-indole-3-carboxamide A mixture of 4-chloro-1H-indole-3-carboxylic acid (0.300 g, 1.5 mmol), (3,3-difluoro-5 methylcyclohexyl)methanamine (0.245 g, 1.5 mmol), HATU (0.684 g, 1.8 mmol) and DIPEA (0.387 g, 3.0 mmol) in DMF (15 mL) was stirred at room temperature for 4 h. The mixture was poured into water (15 mL), extracted with EtOAc (40 mL*3). The combined organic layers were dried over Na2SO4, filtered, concentrated and purified by column chromatography on silica gel (petroleum ether_EtOAc=5:1) to give 4-chloro-N-((3,3-difluoro-5-methyl-cyclohexyl)methyl)-1H-indole-3-carboxamide (0.110 g, 22percent) as a white solid.
23872-36-8, The synthetic route of 23872-36-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Merck Patent GmbH; KARRA, Srinivasa R.; (153 pag.)US2016/168090; (2016); A1;,
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