With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.26340-49-8,2-Iodo-1H-indole,as a common compound, the synthetic route is as follows.
26340-49-8, To dry is added into the reactor 1, 3, 5, 7 – four (3, 5 – diiodosalicylic -4 – octoxy) phenyl nitrogen mixed fluorine boron glimmer (403.4 mg, 0 . 20 mmol), 3 – (2 – iodo) indole (145.8 mg, 0 . 60 mmol), copper acetate (109.0 mg, 0 . 60 mmol), 2, 2 – bipyridyl (15.6 mg, 50 mol %), tetrabutyl ammonium fluoride (104.6 mg, 0 . 40 mmol), 1, 2 – dichloroethane (0.5 ml), acetonitrile (0.5 ml), under the protection of nitrogen, in the 120 C reaction under the condition of 2 hours. Cooling to room temperature after the completion of reaction, adding 10 ml dichloromethane dilution, then diatomite filter in combination with 10 – 20 ml of dichloromethane washing, removal of the solvent under reduced pressure, the residue by silica gel column chromatography (eluant: gradient elution: ethyl acetate/petroleum ether/dichloromethane=1/10/1 – 1/6/1, v/v) separation and purification, after vacuum drying to have a metallic luster of the brown solid target product R1 For 4 – dimethylamino, R2 For the 5 – cyano, R3 For the 5, 7 – dimethyl -7 carboxyl substituted indole target product 274.9 mg, yield 55%.
As the paragraph descriping shows that 26340-49-8 is playing an increasingly important role.
Reference£º
Patent; Sichuan University; Wu Di; Jiang Ruyong; You Jingsong; (10 pag.)CN107189488; (2017); A;,
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