With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.288385-88-6,4-Fluoro-5-hydroxy-2-methylindole,as a common compound, the synthetic route is as follows.
(5) 4-Chloro-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline 7 (37.78 g) obtained in step (4)7.12mol)An organic solvent, N,N-dimethylformamide (DMF) (250 ml), was added to the reaction vessel.After stirring,The catalyst potassium carbonate is added under heating in a water bath.5-Hydroxy-4-fluoro-2-methyl oxime 8 (30 g, 6.57 mol),Slowly increasing the temperature for the condensation reaction,After the end of the reaction, cool down to below 10C by cooling with an ice water bath.Slowly instill pure water and stir until the turbidity is suspended.After separation of the organic phase, the extract was extracted with an extraction agent isopropyl ether (240 ml) into the aqueous layer.After the phases are combined with the extracted organic phase, they are washed with pure water for four times, and finally the isopropyl ether of the extractant is recovered under reduced pressure to obtain 4-(4-Fluoro-).2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline 9 (55.2 g,9.6 mol)., 288385-88-6
The synthetic route of 288385-88-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Dong Dandan; (9 pag.)CN107935998; (2018); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles